mixed lineage kinase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6057	URMC-099		ROCK , MLK , VEGFR , SGK , DNA Alkylation , Trk receptor , c-Met/HGFR , LRRK2 , MEK , IGF-1R , Syk , Bcr-Abl , CDK , Src , Aurora Kinase , Autophagy
	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
T6904	Necrosulfonamide	(E)-Necrosulfonamide	MLK
	(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during nec...		MLK
T11520	GW806742X		MLK , VEGFR
	GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.		MLK , VEGFR
T17010	TC13172		Others
	TC13172 is an inhibitor of mixed lineage kinase domain-like protein (EC50: 2 nM for HT-29 cells).		Others
T39102	MLK-IN-1
	MLK-IN-1 (US20140256733A1, compound 68) is a highly potent and selective inhibitor of mixed lineage kinase 3 (MLK-3). It exhibits excellent brain penetration and specifically targets MLK-3.
T79731	MLKL-IN-6		Necroptosis
	MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein. It effectively prevents MLKL phosphorylation and oligomerization, which are crit...		Necroptosis
T74681	NecroIr2
	NecroIr2, an iridium(III) complex, functions as a necroptosis inducer in cisplatin-resistant lung cancer cells (A549R). It preferentially accumulates in mitochondria, causing oxidative stress and a reduction in mitochond...
T74680	NecroIr1
	NecroIr1, an iridium(III) complex, acts as a necroptosis inducer in Cisplatin-resistant lung cancer cells (A549R). It selectively targets mitochondria, causing oxidative stress and reducing mitochondrial membrane potenti...